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In vitamin B 12 deficiency, the mutase reaction is impaired, causing accumulation of D-methylmalonyl-CoA, which is converted to methylmalonic acid

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Studies in obese Zucker rats and ob/ob murine models demonstrated increased plasma glycerol levels, elevated adipose-tissue lipolysis and significantly reduced body-weight gain without the hyperglycaemia or reduced insulin secretion associated with intact human growth hormone treatment